Publications

2023

Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens 

Awwad SW, Serrano-Benitez A,  Thomas JC, Gupta V, Jackson SP

Nat Rev Mol Cell Biol. NPJ Precis Oncol. 2023 Feb 13. doi: 10.1038/s41580-022-00571-x. PMID: 36781955

2022

Clinical prospects of WRN inhibition as a treatment for MSI tumours 

Morales-Juarez DA,  Jackson SP

NPJ Precis Oncol. 2022 Nov 15;6(1):85. doi: 10.1038/s41698-022-00319-y. PMID: 36379964; PMCID: PMC666358.

POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells 

Schrempf A, Bernardo S, Arasa-Verge EA, Ramirez Otero MA, Wilson J, Kirchofer D, Timelthaler G, Ambros AM, Kaya A, Wieder M, Ecker GF, Winter GE, Costanzo V,  Loizou JI

Cell Rep. 2022 Nov 29;41(9):111716. doi: 10.1016/j.celrep.2022.111716. PMID: 36400033; PMCID: PMC9356142.

Recursive Editing improves homology-directed repair through retargeting of undesired outcomes 

Möller L, Aird EJ, Schröder MS, Kobel L, Kissling L, van den Venn L, Corn JE

Nature Commun. 2022 Aug 5;13(1):4550. doi: 10.1038/s41467-022-31944-7. Epub ahead of print. PMID: 35931681.

Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy

Moretton A, Slyskova J, Simaan ME, Arasa-Verge EA, Meyenberg M, Cerrón-Infantes DA, Unterlass MM, Loizou JI 

Front Oncol. 2022 Jun 2;12:874201. doi: 10.3389/fonc.2022.874201. PMID: 35719993; PMCID: PMC9202558.

Exploring the genetic space of the DNA damage response for cancer therapy through CRISPR-based screens

Wilson J, Loizou JI 

Mol Oncol. 2022 Jun 16. doi: 10.1002/1878-0261.13272. Epub ahead of print. PMID: 35708734.

Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

Ferreira da Silva J, Oliveira GP, Arasa-Verge EA, Kagiou C, Moretton A, Timelthaler G, Jiricny J, Loizou JI

Nat Commun. 2022 Feb 9;13(1):760. doi: 10.1038/s41467-022-28442-1. PMID: 35140211; PMCID: PMC8828784.

2020

Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy

Schrempf A, Slyskova J, Loizou JI

Trends Cancer. 2021 Feb;7(2):98-111. doi: 10.1016/j.trecan.2020.09.007. Epub 2020 Oct 24. PMID: 33109489.