Publications

2023

Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity

Serrano-Benitez A, Wells SE, Drummond-Clarke L, Russo LC,  Thomas JC, LEal GA, Farrow M, Edgerton JM, Balasubramanian S, Yang M, Frezza C, Gautam A, Brazina J, Burdova K, Hoch NC, Gupta V, Jackson SP, Caldecott KW

EMBO J. 2023 Sep 18;42(18):e113190. doi: 10.15252/embj.2022113190. PMID: 37492888. PMCID: PMC10505916.

  Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens 

   Awwad SW, Serrano-Benitez A,  Thomas JC, Gupta V, Jackson SP

Nat Rev Mol Cell Biol.  2023 Feb 13. doi: 10.1038/s41580-022-00571-x. PMID: 36781955

2022

Clinical prospects of WRN inhibition as a treatment for MSI tumours 

Morales-Juarez DA,  Jackson SP

NPJ Precis Oncol. 2022 Nov 15;6(1):85. doi: 10.1038/s41698-022-00319-y. PMID: 36379964; PMCID: PMC666358.

POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells 

Schrempf A, Bernardo S, Arasa-Verge EA, Ramirez Otero MA, Wilson J, Kirchofer D, Timelthaler G, Ambros AM, Kaya A, Wieder M, Ecker GF, Winter GE, Costanzo V,  Loizou JI

Cell Rep. 2022 Nov 29;41(9):111716. doi: 10.1016/j.celrep.2022.111716. PMID: 36400033; PMCID: PMC9356142.

Recursive Editing improves homology-directed repair through retargeting of undesired outcomes 

Möller L, Aird EJ, Schröder MS, Kobel L, Kissling L, van den Venn L, Corn JE

Nature Commun. 2022 Aug 5;13(1):4550. doi: 10.1038/s41467-022-31944-7. Epub ahead of print. PMID: 35931681.

Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy

Moretton A, Slyskova J, Simaan ME, Arasa-Verge EA, Meyenberg M, Cerrón-Infantes DA, Unterlass MM, Loizou JI 

Front Oncol. 2022 Jun 2;12:874201. doi: 10.3389/fonc.2022.874201. PMID: 35719993; PMCID: PMC9202558.

Exploring the genetic space of the DNA damage response for cancer therapy through CRISPR-based screens

Wilson J, Loizou JI 

Mol Oncol. 2022 Jun 16. doi: 10.1002/1878-0261.13272. Epub ahead of print. PMID: 35708734.

Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

Ferreira da Silva J, Oliveira GP, Arasa-Verge EA, Kagiou C, Moretton A, Timelthaler G, Jiricny J, Loizou JI

Nat Commun. 2022 Feb 9;13(1):760. doi: 10.1038/s41467-022-28442-1. PMID: 35140211; PMCID: PMC8828784.

2020

Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy

Schrempf A, Slyskova J, Loizou JI

Trends Cancer. 2021 Feb;7(2):98-111. doi: 10.1016/j.trecan.2020.09.007. Epub 2020 Oct 24. PMID: 33109489.