Publications

2022


Recursive Editing improves homology-directed repair through retargeting of undesired outcomes

Möller L, Aird EJ, Schröder MS, Kobel L, Kissling L, van den Venn L, Corn JE

Nature Commun. 2022 Aug 5;13(1):4550. doi: 10.1038/s41467-022-31944-7. PMID: 35931681; PMCID: PMC9356142.


Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy

Moretton A, Slyskova J, Simaan ME, Arasa-Verge EA, Meyenberg M, Cerrón-Infantes DA, Unterlass MM, Loizou JI

Front Oncol. 2022 Jun 2;12:874201. doi: 10.3389/fonc.2022.874201. PMID: 35719993; PMCID: PMC9202558.


Exploring the genetic space of the DNA damage response for cancer therapy through CRISPR-based screens

Wilson J, Loizou JI

Mol Oncol. 2022 Jun 16. doi: 10.1002/1878-0261.13272. Epub ahead of print. PMID: 35708734.


Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

Ferreira da Silva J, Oliveira GP, Arasa-Verge EA, Kagiou C, Moretton A, Timelthaler G, Jiricny J, Loizou JI

Nat Commun. 2022 Feb 9;13(1):760. doi: 10.1038/s41467-022-28442-1. PMID: 35140211; PMCID: PMC8828784.

2021

Double stranded DNA breaks and genome editing trigger loss of ribosomal protein

Riepe C, Zelin E, Frankino PA, Meacham ZA, Fernandez SG, Ingolia NT, Corn JE

RPS27A. FEBS J. 2021 Dec 16. doi: 10.1111/febs.16321. Epub ahead of print. PMID:34914197.


Tissue specificity of DNA repair: the CRISPR compass

Ferreira da Silva J, Meyenberg M, Loizou JI

Trends Genet. 2021 Nov;37(11):958-962. doi: 10.1016/j.tig.2021.07.010. Epub 2021 Aug 12. PMID: 34392967.


Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing

Meyenberg M, Ferreira da Silva J, Loizou JI

Front Genet. 2021 Sep 3;12:728520. doi: 10.3389/fgene.2021.728520. PMID: 34539755; PMCID: PMC8446275.


PnB Designer: a web application to design prime and base editor guide RNAs for animals and plants

Siegner SM, Karasu ME, Schröder MS, Kontarakis Z, Corn JE

BMC Bioinformatics. 2021 Mar 2;22(1):101. doi:10.1186/s12859-021-04034-6. PMID: 33653259; PMCID: PMC7923538.


2020

Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy

Schrempf A, Slyskova J, Loizou JI

Trends Cancer. 2021 Feb;7(2):98-111. doi: 10.1016/j.trecan.2020.09.007. Epub 2020 Oct 24. PMID: 33109489.