Jacob Corn is the Professor of Genome Biology at ETH Zürich. His research aims to bring about the end of genetic disease through the development and application of next-generation genome editing technologies. In his spare time, Jacob enjoys long backpacking trips and rock climbing. You can find Jacob on Twitter and LinkedIn.
Steve Jackson FRS, FMedSci is University of Cambridge Professor of Biology, and Senior Group Leader at the Cancer Research UK Cambridge Institute, University of Cambridge. His research has identified many key principles by which cells respond to and repair DNA damage. This work identified many DNA repair proteins, established how they function, and showed how their dysfunction yields cancer and other age-related diseases.
To translate his work towards patient benefit, Steve has founded/co-founded several biotechnology companies. One of these, KuDOS, generated the PARP inhibitor drug olaparib/LynparzaTM that is marketed worldwide by AstraZeneca for treating certain ovarian and breast cancers. In 2010, Steve founded Mission Therapeutics Ltd. (Babraham, Cambridge) to exploit recent advances in protein ubiquitylation and deubiquitylation to derive new medicines. Steve’s academic laboratory is currently further defining mechanisms of DNA repair and associated processes, with a view to identifying new therapeutic opportunities for cancer as well as various other genetic diseases.
Markus received his PhD in Computational Infection Biology from University College Dublin, Ireland, working with Prof. Geraldine Butler and Prof. Des Higgins on comparative genomics in human fungal pathogens, focusing on uncovering the population structure and characterizing transcriptional networks in Candida species. Markus joined the Corn lab staff as a Bioinformatics Scientist in May 2019 from Genentech, South San Francisco, where he worked on large scale cancer genomics and familial data sets. At ETHZ, he works on CRISPR- and NGS-related computational approaches and is part of the NCCR RNA & Disease.
I am a senior postdoctoral scientist and have been working in the Jackson lab as Information Specialist for over 15 years. My role is to facilitate all aspects of science management and administration for Professor Jackson. This is a diverse role and I wear many hats; everything from monitoring the scientific literature, writing reports and grant applications, to editing Wikipedia pages. I also oversee lab funding and staff recruitment, assist with research publications from first drafts to final proof-reading, write press releases, curate the lab website and Twitter feed, and deal with anything else that crosses my desk!
Lena Kobel received her Master’s degree in Cell Biology from the ETH Zürich in 2017. In her Master thesis she focused on generating stable mammalian cell lines using CRISPR-Cas9 in the lab of Prof. Martin Jinek at the University of Zürich, where she then worked for another 1.5 years as a technician. After that, she worked as an intern at Caribou Biosciences, Inc., in Berkeley for 6 months on a project focused on the development of CAR-T cell therapies. Lena joined the Corn lab as a Cell Line Engineer in March 2020.
I am a Senior Research Associate with Prof. Steve Jackson at the Cancer Research UK Cambridge Institute, University of Cambridge. Originally from Israel, I completed my PhD in 2005 on ATM and the COP9- signalosome in the DDR at Tel-Aviv Medical School with Prof. Yossi Shiloh. I then joined Prof. Steve Jackson’s lab as a postdoctoral researcher, where I spearheaded projects exploring the role of ubiquitin and other UBLs (ubiquitin-like proteins) in DDR signalling and repair. In 2009, following seminal publications on the roles of SUMO in the DDR, I accepted a permanent position as a senior research associate in the lab. Since then I have supervised research projects, graduate and undergraduate students, while continuing with my own research projects and spearhead the introduction of CRISPR technology to the lab.
Moritz Schlapansky received his Master’s degree in Molecular Biology from the University of Vienna in 2020. He worked in the laboratory of Professor Michael McManus at UCSF, focusing on the development of a novel genetic screening paradigm and targeted sequencing approaches in order to decipher cell state transitions. Moritz joined the Corn Lab as a PhD student in July 2020. He is using the CRISPR toolbox to delineate genetic interactions that could inspire new cancer therapeutics. Moritz’ research interests include functional genomics, therapeutic gene editing and cancer biology, with a special focus on technology development.
Giuseppina is a postdoctoral fellow and joined the Steve Jackson group in January 2019. She is interested in the role of lncRNAs (long non-coding RNAs) in the DNA damage response.
John received his PhD in Oncology from the University of Oxford in 2020, working with Prof. Kristijan Ramadan on the molecular mechanisms of DNA-protein crosslink repair. John joined the Corn Lab as a postdoctoral researcher in October 2020, where he is using CRISPR-Cas9-based screening approaches to identify genetic interactions that can be exploited in cancer therapy.
Simon is a postdoctoral bioinformatician at Cancer Research UK Cambridge Institute, University of Cambridge. He completed his PhD at King’s College London where he constructed mathematical models of metabolism in human diseases. Simon’s research is focused on nucleotide metabolism in DDR as well as cancer multi-omics and CRISPR screen library design. His wider research interests includeexecutable biology, computational biology, and machine learning.
Sebastian Siegner received his MSc in Biochemistry from ETH Zurich in December 2020 with his work on the therapeutic potential of CRISPR Base- and Prime-Editors for the genetic disease Fanconi Anemia.
Originally from St. Petersburg, Russia, Rimma received her Master’s diploma from the Department of Genetics of the State University of St. Petersburg. She earned her Ph.D. from the University of Pennsylvania studying regulation of gene expression by histone acetyltransferase SAGA complex in the laboratory of Shelley Berger. Her postdoctoral research in Danny Reinberg’s lab at the UMDNJ helped to explain how histone chaperone FACT promotes gene transcription in the context of chromatin. Since joining Steve Jackson’s group in 2004, Rimma has studied various aspects of the DNA damage response and contributed to multiple projects. The main research interest is in understanding of the interplay between different DNA double-strand break repair pathways, especially in the context of acquired drug resistance in homology directed repair-deficient tumours.
Eric received his PhD in Biochemistry, Molecular Biology, and Biophysics from the University of Minnesota in 2020 in the lab of Dr. Wendy Gordon developing improved genome editing technologies, including a Cas-DNA tethering platform. In November 2020, Eric joined the Corn Lab as a postdoc interested in studying synthetic lethalities and viabilities in DNA repair utilizing CRISPR.
Bioinformatist at Jackson Lab
David received his PhD in Biochemistry from the University of Cambridge in 2022 under the supervision of Prof. Steve Jackson. His work focused on identifying functional genetic inter-actions within the DNA damage response through CRISPR-Cas9 screens. David joined the Corn Lab as a post doctoral researcher in October 2022. His research interests include DNA repair, CRISPR-Cas9 technologies, genetic screening, and therapeutic gene editing.
For the past 7 years I was a lab manager and research assistant in Petra Beli’s lab in Mainz, using quantitative proteomics approaches to study the DNA damage response. I am excited to join the DDREAMM project in the Jackson lab as a research assistant.
Ana joined the Corn Lab as a Program Manager in September 2022. She will contribute to scientifi c management on several fronts, including national and international collaborative projects. She received her PhD in Cancer Biology at the University of Zurich and has a strong track record as an independent group leader. Most recently she was a clinical scientist in industry.
I joined Steve Jackson’s lab as a postdoc in January 2020. I obtained my PhD degree investigating how DSBs generated by topoisomerase II are repaired in different genetic backgrounds and what are the consequences for the genome stability. I’m interested in studying molecular mechanisms of the DNA damage response and its interplay with topoisomerases, as well as using CRISPR-Cas9 technology to identify unknown factors involved in these processes.