DNA Damage REsponse: Actionabilities, Maps and Mechanisms
The DNA in our cells is damaged every time we go out in the sun, drink a glass of wine or even just sit perfectly still. Thankfully, multicellular organisms have evolved a dizzying number of ways to fix DNA damage called the DNA-damage response (DDR); a complex collective set of mechanisms that detect DNA lesions, signal their presence and promote their repair. While DNA repair pathways have recently been exploited to treat diseases, the mechanisms are not fully understood.
The EU-funded DDREAMM project is a collaboration between three labs investigating DDR pathways to identify factors that confer sensitivity to DNA-damaging agents, DDR deficiency, and resistance to DDR-targeting treatments. This project will lead to insights into human genome surveillance, generate tools allowing precise control of DNA repair and speed the development of new therapies for cancer and other diseases.
14 June 2021
02 June 2020
The DDREAMM website goes live today!